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Neocutis vs SkinMedica (The Definitive Guide)

We all want to look and feel our best, and a good skincare routine is an essential part of that. The right products will keep our skin nourished, healthy, glowing and looking more youthful.

Products that have surged in popularity over the past few years are serums, with many people taking on the additional step during their morning and nighttime routines to target specific needs like anti-aging, dark spots, or hydration.

If you’re looking for a serum that focuses on anti-aging and skin rejuvenation, then Neocutis and SkinMedica may have what you’re looking for. Both companies boast products that specifically focus on turning back the clock when it comes to the appearance of your skin.

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Neocutis vs SkinMedica

Serums are able to penetrate your skin and deliver active ingredients deeply for increased efficacy. If you’re finding your skin in need of an anti-aging boost, a serum could be just what your skin needs!

Let’s look at two of the most highly-rated and awarded serums on the market: Neocutis Bio Serum Firm vs Skinmedica’s TNS Advanced+ Serum.


SkinMedica’s TNS Advanced+ Serum is a “supercharged” version of the company’s classic formula, with the California company saying its newer serum is even better at softening wrinkles, diminishing dark spots, and addressing other signs of aging.

The formula is fragrance-free and paraben-free and is designed for all mature skin types, including sensitive, dry, combination and oily skin.

The Advanced Serum is made up of an impressive list of ingredients to visibly firm and smooth fine lines and wrinkles, including Spanish marine extract and green microalgae to build collagen and support your skin’s repair process. SkinMedica’s serum is also made up of a Tissue Nutrient Solution (TNS), which is the company’s patented growth factor blend.

If you’re wondering how long you need to use the product to start seeing a difference, SkinMedica guarantees the serum will deliver results in as little as two weeks and those results will continue to improve over 24 weeks.

The product isn’t cheap at ~$300 a bottle, but with a 4.6-star rating on the official site, customers call it a “game changer” and say it’s worth the money. Many customers say they have seen a noticeable difference in their face’s texture and that’s why they keep going back for more.

If you’re looking for even faster results, Swiss company Neocutis says its Bio Serum Firm will leave your skin looking and feeling smoother, brighter, and tighter in less than a week and those results will be amplified by eight weeks.

This serum has a high concentration of peptides and human growth factors which will restore collagen, elastin, and your skin’s natural supply of hyaluronic acid.

The formula is also super nourishing with its star ingredient being sodium hyaluronate, which is the salt form of hyaluronic acid. This ingredient will prevent your skin from losing moisture as well as reduce inflammation.

The non-comedogenic and dermatologist-tested formula is free of parabens, silicones, and fragrances. It is suitable for all mature skin types, including sensitive, dry, oily and combination skin.

This serum is also on the pricier end, selling at more or less the same as its SkinMedica counterpart per bottle. However, with a 4.7-star rating on the official site, customers are raving about the product, saying it’s an “investment for your skin”. Many shoppers are crediting the serum for diminishing fine lines and wrinkles and for providing their skin with a gorgeous glow.


Both the SkinMedica TNS Advanced+ Serum and Neocutis Bio Serum Firm have similar price points and offer similar benefits. The two formulas have garnered an impressive fanbase with customers expressing amazing results. This makes for a tough decision on which serum is the better option.

Overall, it seems SkinMedica’s serum is the more popular of the two, and for that reason alone we would choose their product. However, it’s such a close call that you certainly wouldn't be blamed for leaning the other way.

Bio Serum Firm by Neocutis, Rejuvenating Growth Factor and Peptide Treatment.

Bio Serum Firm by Neocutis

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Our rating: ★★★★★

Price: $$$$

Rejuvenating Growth Factor and Peptide Treatment.

What makes it special? Time is precious. Make it count with the only Human Growth Factors + Proprietary Peptides anti-aging formulation with proven results in less than a week. Minimize the appearance of fine lines and wrinkles, refines texture, brightens skin tone, improves firmness and elasticity, and boosts hydration as soon as 6 days.

Which skin types? For all skin types.

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TNS Advanced+ Serum by SkinMedica, skin rejuvenating formula improves the appearance of coarse wrinkles, fine lines, skin tone, and texture.

TNS Advanced+ Serum by SkinMedica

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Our rating: ★★★★★

Price: $$$$

Skin rejuvenating formula improves the appearance of coarse wrinkles, fine lines, skin tone, and texture.

What makes it special? Coined as a next-generation skin rejuvenator, this formula utilizes TNS®-MR (a unique growth factor blend and peptide complex) and Renessence (RSC) Advanced (a blend of botanicals, marine extracts, and peptides) to provide results in just 2 weeks!

Which skin types? For all skin types.

Find the best price on Amazon

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